Sphingolipids in cardiovascular diseases and metabolic disorders
نویسندگان
چکیده
منابع مشابه
Implication of hepatokines in metabolic disorders and cardiovascular diseases.
The liver is a central regulator of systemic energy homeostasis and has a pivotal role in glucose and lipid metabolism. Impaired gluconeogenesis and dyslipidemia are often observed in patients with nonalcoholic fatty liver disease (NAFLD). The liver is now recognized to be an endocrine organ that secretes hepatokines, which are proteins that regulate systemic metabolism and energy homeostasis. ...
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Bioactive sphingolipids are engaged with numerous cellular processes such as cell differentiation, proliferation and apoptosis. Sphingolipid metabolism in heart is regulated by physical exercise and PPARs. Ceramide, the main second messenger of sphingomyelin pathway of signal transduction, was found to be involved in development of cardiac dysfunction after ischemia/reperfusion. On the other ha...
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ژورنال
عنوان ژورنال: Lipids in Health and Disease
سال: 2015
ISSN: 1476-511X
DOI: 10.1186/s12944-015-0053-y